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Research programs running longer or higher-volume protocols may find the 15mg vial more efficient, provided their storage setup can reliably maintain a reconstituted solutions stability across its full usable window

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In patients treated with semaglutide, median duration of nausea was 8 days, vomiting 2 days, diarrhoea 3 days, and constipation 47 days. Over the 68-week trial period nausea occurred in 43.9% of patients (16.1% placebo)